1. Introduction
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名称
替尔泊肽
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CAS号
2023788-19-2
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分子式
C225H348N48O68
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分子量
4813.45
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适应症
Treat type 2 diabetes
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药理学
GIP is a hormone that may complement the effects of GLP-1 receptor agonists. In preclinical models, GIP has been shown to decrease food intake and increase energy expenditure therefore resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids.
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给药途径
subcutaneous injection
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禁忌
Tirzepatide is not suitable for patients with medullary thyroid cancer
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作用靶点
GLP Receptor
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序列号
Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{Aib}-Leu-Asp-Lys-Ile-Ala-Gln-{C20 diacid-gamma-Glu-(Ala-Glu-Glu-Ala)2-Lys}-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
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短序列号
Y-{Aib}-EGTFTSDYSI-{Aib}-LDKIAQ-{C20 diacid-gamma-Glu-(PEG2)2-Lys}-AFVQWLIAGGPSSGAPPPS-NH2
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国际标识符代码
BTSOGEDATSQOAF-SMAAHMJQSA-N
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溶解度
100 mg/mL
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纯度
≥99%
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引用文献
[1]. Fontanella RA, et al. Tirzepatide prevents neurodegeneration through multiple molecular pathways. J Transl Med. 2024 Jan 29;22(1):114. [2]. Huang L, et al. Tirzepatide inhibits tumor growth in mice with diet-induced obesity. bioRxiv, 2023: 2023.06. 22.546093. [3]. Guo X, et al. Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats. Front Pharmacol. 2023 Aug 28;14:1146960.
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2. Specification
| 检验项目Tests | 标准Specifications | 结果Results |
| 外观Appearance | 白色粉末White powder | 符合Conforms |
| 溶解性Solubility | 易溶于水Freely soluble in water | 符合Conforms |
| 酸碱度pH | 6.0-9.0 | 7.5 |
| 氨基酸Amino acid analysis | 符合Conform | 符合Conform |
| 醋酸Acetic acid | <0.5% | 0.0% |
| 三氟乙酸TFA | <0.5% | 0.0% |
| 水分Water Content | ≤10.0% | 5.6% |
| 钠盐Sodium ion | ≤5.0% | 1.6% |
| 纯度Purity（HPLC） | ≥ 99.0% | 99.5% |
| ImpurityⅠ:NMT 0.3% | N.D | |
| ImpurityⅡ:NMT 0.3% | 0.27% | |
| ImpurityⅢ:NMT 0.3% | 0.09% | |
| ImpurityIV:NMT 0.3% | N.D | |
| Any individual impurity: NMT 0.3% | 0.08% | |
| Total impurities:NMT1.5% | 0.45% | |
| 分子量Mass spectrum | 4813.4±1.0 | 符合Conform |
| 细菌内毒素Bacterial endotoxins | <5EU/mg | 符合Conform |
| 肽含量Peptide content | ≥85.0% | 94.1% |
| 高分子多肽 High molecular protein | ≤0.5% | 0.05% |
| 微生物限度Microbial Limits | 总需氧数≤1000cfu/g | 少于20cfu/g |
| Total aerobic microbial count ≤1000cfu/g | Less than 20cfu/g | |
| 霉菌和酵母菌数≤100cfu/g | 少于20cfu/g | |
| Total yeast and mold count ≤100cfu/g | Less than 20cfu/g | |
| 不得检出大肠杆菌 | 未检出 | |
| Escherichia coli:Absent | Absent | |
| 残留溶剂residual solvents | 乙腈Acetonitrile≤410ppm | 70ppm |
| 甲醇 Methanol≤3000ppm | N.D | |
| 哌啶Piperidine≤5000ppm | N.D | |
| N’N-二甲基甲酰胺DMF≤880ppm | N.D | |
| 三乙胺Triethylamine ≤320ppm | N.D | |
| 二氯甲烷DCM≤600ppm | N.D | |
| 含量Assay（HPLC） | 95.0%-105.0% | 99.6% |
Note:This product is intended for research use only！
3. Storage
Packed in composite film bag or plastic bottle，≤ -20℃.
4.Contact Us
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